Martin Scorsese casts Lily Gladstone as Leonardo DiCaprio’s wife in Killers Of The Flower Moon

Martin Scorsese casts Lily Gladstone as Leonardo DiCaprio’s wife in Apple Original Film Killers Of The Flower Moon

With filming set to get underway this spring, Martin Scorsese has cast the female lead for his highly-anticipated new movie Killers of The Flower Moon.

The veteran director has tapped actress Lily Gladstone, 34, to star opposite Robert De Niro and Leonardo DiCaprio in the based on a true story Apple Original Film, Variety reported Thursday.

It’s a major breakthrough for Gladstone who is relatively unknown with roles in just a handful of productions including the 2016 independent drama Certain Women and the Showtime series Billions in 2019.

Big break: Lily Gladstone, 34, (pictured in 2018) has been cast as the wife of Leonardo DiCaprio in Martin Scorsese’s Apple Original Film Killers of The Flower Moon, it was reported Thursday

Killers Of The Flower Moon is adapted from David Grann’s best-selling true crime book of the same name about the brutal murders of Osage Nation Native Americans in 1920s Oklahoma.

The killings became known as the Reign Of Terror and became one of the first major cases to be investigated by the then newly-formed FBI.

The murders began after oil was found on land belonging to the Osage Nation.

Based on a true story: Scorsese is directing the drama about the brutal murders of Osage Nation Native Americans in 1920s Oklahoma after oil was discovered on their tribal lands

Based on a true story: Scorsese is directing the drama about the brutal murders of Osage Nation Native Americans in 1920s Oklahoma after oil was discovered on their tribal lands

Robert De Niro, who last worked with Scorsese on Netflix's The Irishman, stars as a powerful Oklahoma rancher William Hale

Leonardo DiCaprio DiCaprio plays Hale's nephew Ernest Burkhart, who is married to an Osage woman, in what will be his sixth collaboration with Scorsese

Scorsese collaborators: Robert De Niro stars as a powerful Oklahoma rancher William Hale while DiCaprio plays Hale’s nephew Ernest Burkhart, who is married to an Osage woman

De Niro plays a powerful Oklahoma rancher William Hale.

DiCaprio plays Hale’s nephew Ernest Burkhart and Gladstone will play DiCaprio’s wife Mollie, a member of the Osage Nation.

Gladstone herself is descended from the Blackfeet and Nez Perce tribes.

According to local news outlets in Oklahoma, filming is set to take place from spring to late summer in the Tulsa, Bartlesville and Osage County area.

A virtual casting call for extras was announced last month. 

The production is reported to have an estimated budget of $200 million and will be Scorsese’s first film since the 2019 Netflix hit The Irishman. 

Set for stardom: Gladstone, who is descended from the Blackfeet and Nez Perce tribes, is relatively unknown with roles in just a handful of productions including the 2016 independent drama Certain Women and the Showtime series Billions in 2019

Set for stardom: Gladstone, who is descended from the Blackfeet and Nez Perce tribes, is relatively unknown with roles in just a handful of productions including the 2016 independent drama Certain Women and the Showtime series Billions in 2019

History: Killers Of The Flower Moon is adapted from David Grann's best-selling true crime book of the same name and filming is set to begin this spring in Oklahoma

History: Killers Of The Flower Moon is adapted from David Grann’s best-selling true crime book of the same name and filming is set to begin this spring in Oklahoma